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Spinal cord implant helps paralyzed patients walk again |

Health And Family

Spinal cord implant helps paralyzed patients walk again

Sara Hussein - Agence France-Presse
Spinal cord implant helps paralyzed patients walk again
This handout picture obtained from Northwestern University on November 10, 2021 shows a longitudinal spinal cord section treated with the most bioactive therapeutic scaffold; regenerated axons (red) regrew within the lesion. US scientists have developed a new form of drug that promotes the regeneration of cells and reversed paralysis in mice with spinal injuries, allowing them to walk again within four weeks of treatment. The research was published in the journal Science on November 11, 2021, and the team of Northwestern University scientists behind it hope to approach the Food and Drug Administration to start human trials as early this year. "The aim of our research was to develop a translatable therapy that could be brought to the clinic to prevent individuals from becoming paralyzed after major trauma or disease," Northwestern's Samuel Stupp, who led the study, told AFP.
Handout / Northwestern University / AFP

TOKYO — In 2017, Michel Roccati was in a motorbike accident that left his lower body completely paralysed. In 2020, he walked again, thanks to a breakthrough new spinal cord implant.

The implant sends electrical pulses to his muscles, mimicking the action of the brain, and could one day help people with severe spinal injuries stand, walk and exercise.

It builds on long-running research into using electrical pulses to improve quality of life for people with spinal cord injuries, including a 2018 study by the same team that helped people with partial lower-body paralysis walk again.

"It was a very emotional experience," Roccati told journalists of the first time the electrical pulses were activated and he took a step.

He was one of three patients involved in the study, published Monday in the journal Nature Medicine, all of them unable to move their lower bodies after accidents.

But the three were able to take steps shortly after the six-centimetre implant was inserted and its pulses were fine-tuned.

"These electrodes were longer and larger than the ones we had previously implanted, and we could access more muscles thanks to this new technology," said Jocelyne Bloch, a neurosurgeon at the Lausanne University Hospital who helped lead the trial.

Those initial steps, while breathtaking for the researchers and their patients, were difficult and required support bars and significant upper body strength.

But the patients could start rehabilitation immediately, and within four months Roccati could walk with only a frame for balance.

"It's not that it's a miracle right away, not by far," cautioned Gregoire Courtine, a neuroscientist at the Swiss Federal Institute of Technology who led the research with Bloch.

Roccati is now "able to stand for two hours -- he walks almost one kilometre without stopping".

The Italian described being able to look clients in the eye, have a drink at a standing table and take a shower standing up thanks to the implant.

He and others in the trial were also able to climb stairs, swim and canoe.

'Bright future' 

The improvements depend on the electrical stimulation, which is triggered via a computer carried by the patient that activates a pattern of pulses.

Two of the patients can now activate their muscles slightly without electrical pulses, but only minimally.

The three men had all been injured at least a year before the study and Bloch said the team hopes to trial the technology with people sooner after an accident.

"What we all think is that if you try earlier it will have more effect," she said.

There are challenges: in early recovery a patient's capacity is still in flux, making it hard to set a baseline from which to measure progress, and ongoing medical treatment and pain could hamper rehabilitation.

So far, the implants are also only suitable for those with an injury above the lower thoracic spinal cord, the section running from the base of the neck to the abdomen, because six centimetres of healthy spinal cord is needed.

The idea of using electrical pulses to address paralysis stemmed from technology used to regulate pain, and the researchers said they see scope for further applications.

They have also shown it can regulate low blood pressure in spinal cord injury patients and plan to soon release a study on its use for severe Parkinson's disease.

The team cautioned that significant work remains before the implant is available for treatment outside clinical studies, with Bloch saying she and Courtine receive around five messages a day from would-be patients seeking help.

They next plan to miniaturise the computer that activates the pulses so it too can be implanted in patients and controlled with a smartphone.

They expect this to be possible this year, and have plans for large-scale trials involving 50-100 patients in the United States and then Europe.

"We believe there is a bright future for neurological stimulation technology," said Courtine.

"We'll do (it) as fast as we can."

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