Rafael Nadal is the first match winner with the roof closed.
The fourth-seeded Spaniard defeated Andreas Seppi 6-0, 7-5, 6-1 to advance to the third round, where he will take on Andrey Kuznetsov of Russia.
Nadal's victory came after the new, $150 million roof in Arthur Ashe Stadium was closed with the score 3-3 in the second set.