At solo second place with a 5-2 (win-loss) record, the Knights are heavily favored over the Altas, down in the standings with only two wins to show in seven games.
Gametime is at 2 p.m.
Letran is expected to lean again on the prolific Ronjay Enrile and a defensive game that has been the Knights main weapon.
"A lot of our opponents think were a quick running team but our real strength is our defense," said Alas, who had a two-year stint as coach in the PBA and the defunct MBA before returning to the Knights fold last year.
The San Sebastian-Mapua duel is also a game to watch.
Tied at fourth spot with 4-3 slates, the Stags and the Cardinals collide at 4 p.m., seeking to join the Jose Rizal Heavy Bombers (5-3) at third.
While the defending champions are hoping to rediscover their deadly form, the Cardinals are aiming to exact revenge on the former after dropping their first round match, 61-63, last July 21.
And like most coaches, Mapua mentor Horacio Lim feels defense would be the key to their bid.
"I wont get tired of saying this but I believe we need to really play tough defense in order to beat a strong team like San Sebastian," said Lim.