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YOUR DOSE OF MEDICINE
First data verify value of early combination therapy in T2D
by Charles C. Chante MD - April 5, 2020 - 12:00am
Upfront use of a dual combination of vildagliptin (Galvus) and metformin was associated with better and more durable glycemic control than metformin alone in patients with newly diagnosed type 2 diabetes, according...
Oral semaglutide monotherapy
by Charles C. Chante MD - March 29, 2020 - 12:00am
Oral semaglutide monotherapy was superior to placebo for improving glycated hemoglobin (HbA1c) levels at all doses tested in adults with type 2 diabetes who had been previously insufficiently managed with diet and...
Using aspirin for primary prevention: The benefits and risks
by Charles C. Chante MD - March 22, 2020 - 12:00am
Using daily aspirin treatment for the primary prevention of cardiovascular events remains an individualized decision that needs to balance a person’s risks for ischemic events and bleeding, according to results...
Study: Office BP is highly predictive for average patient
by Charles C. Chante MD - March 15, 2020 - 12:00am
Continuous blood pressure monitoring is significantly better than in-office measurements at predicting the risk of cardiovascular events and death, although the additional prognostic benefit is quite small.
How thin should we go?
by Charles C. Chante MD - March 8, 2020 - 12:00am
An 88-year-old man with hypertension, chronic obstructive pulmonary disease, and atrial fibrillation presents with severe cerebral palsy and is diagnosed with a non–ST-elevation MI.
Can dietary therapies treat GERD effectively?
by Charles C. Chante MD - March 1, 2020 - 12:00am
Dietary therapies can form a beneficial part of personalized treatment for gastroesophageal reflux disease, according to an overview. Modifying diet may reduce lower esophageal sphincter pressure and decrease the...
Moderate exercise reduced women’s stroke risk
by Charles C. Chante MD - February 23, 2020 - 12:00am
Moderate exercise significantly reduced the risk of stroke in women and seemed to offset much but not all of the increased stroke risk in postmenopausal women on hormone therapy, a large retrospective study fou...
Big drinkers face newly appreciated massive health burden
by Charles C. Chante MD - February 16, 2020 - 12:00am
Individuals who regularly consume alcohol in quantities defined by the World Health Organization as “very high risk” face a daunting and yet widely underappreciated health burden.
Smoking often neglected in peripheral artery disease
by Charles C. Chante MD - February 9, 2020 - 12:00am
Patients with claudication consulting a peripheral arterial disease provider are often active smokers, rarely receive evidence-based cessation interventions, and frequently relapse if they do quit, according to a...
High-sensitivity cardiac tropinin levels linked to poor CV outcomes
by Charles C. Chante MD - February 2, 2020 - 12:00am
In patients with chronic obstructive pulmonary disease and heightened cardiovascular risk, high levels of high-sensitivity cardiac troponin are strongly associated with risk of poor cardiovascular outcomes, according...
Years after allhat, alpha-blocker use common, risky
by Charles C. Chante MD - January 26, 2020 - 12:00am
The risk of cardiovascular and hypotension-related events is higher with alpha-blockers than with other hypertension drugs, but almost 20 years after the pivotal ALLHAT trial first raised safety concerns, they are...
No falls, fractures, or bone density benefits from Vitamin D
by Charles C. Chante MD - January 19, 2020 - 12:00am
There is little justification for the use of vitamin D supplementation for the prevention of fractures or falls or for increasing bone density, according to the authors of a meta-analysis that found no benefits from...
High-dose flu vaccine in rheumatoid arthritis beats standard dose
by Charles C. Chante MD - January 12, 2020 - 12:00am
The administration of high-dose vs. standard-dose influenza vaccine provided substantially better immune responses in seropositive rheumatoid arthritis patients in a randomized, active-controlled trial.
After a fracture, reinforce secondary-prevention message
by Charles C. Chante MD - January 5, 2020 - 12:00am
Ensuring that older adults who have experienced a hip or vertebral fracture understand they likely have osteoporosis, and offering prompt drug treatment for the condition, are among five fundamental recommendations...
No falls, fractures, or bone density benefits from Vitamin D
by Charles C. Chante MD - December 29, 2019 - 12:00am
There is little justification for the use of vitamin D supplementation for the prevention of fractures or falls or for increasing bone density, according to the authors of a meta-analysis that found no benefits from...
Obesity tied to rise of GI, colorectal cancer in younger adults
by Charles C. Chante MD - December 22, 2019 - 12:00am
Researchers have identified a link between obesity and an increased incidence rate of gastrointestinal cancer in younger patients, as well as an increased rate of colorectal, esophageal, and pancreatic cancer resections...
Flu: All that and heart attack too
by Charles C. Chante MD - December 15, 2019 - 12:00am
Myocardial infarction admissions were six times more likely to occur in the week after a positive test for influenza than in the year before or the 51 weeks after the infection, according to analysis of a Canadian...
Long-acting Beta2 agonists didn’t boost BP in COPD
by Charles C. Chante MD - December 8, 2019 - 12:00am
Neither heart rate nor blood pressure worsened under long-term use of long-acting beta2 agonists olodaterol or formoterol in patients with chronic obstructive pulmonary disease, according to a post hoc pooled analysis...
‘Undetectable’ HIV means ‘untransmissible’ confirmed in larger sex study
by Charles C. Chante MD - December 1, 2019 - 12:00am
One maxim of current HIV management is U=U; Undetectable equals Untransmissible, and it received new backing for the specific question of whether HIV treated to an undetectable level can transmit from a man who engages...
Next-gen sputum PCR panel boosts CAP diagnostics
by Charles C. Chante MD - November 24, 2019 - 12:00am
A next-generation lower respiratory tract sputum polymerase chain reaction film array panel identified etiologic pathogens in 100 percent of a group of patients hospitalized for community-acquired pneumonia.
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