Kampanerang Kuba is a casting coup of sorts for the network, as it also brings together acclaimed actresses Eula Valdez and Jean Garcia for their first project together since their career-reviving performances in Pangako Sa Yo. Also on hand is Jomari Yllana, who returns to ABS-CBN for the first time in years. Joining Anne, Eula, Jean and Jomari are Jodi Sta. Maria, who plays her first villain role as the Kampaneras main antagonist, and Patrick Garcia. Making his TV acting debut is Christian Bautista as the shows other leading man.
Creating Annes prosthetic makeup is artist Rene Abelardo, who also created prosthetic effects for Marina, including the shows mermaids tails.